Amino Acid Receptor Research by Benjamin F. Paley, Tomas E. Warfield

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By Benjamin F. Paley, Tomas E. Warfield

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The carboxy terminal domain in the intracellular face of plasma membrane contains several motifs of interaction with signal transduction and scaffold proteins, implicated in localization, traffic and function of iGluRs (reviewed in Chen and Wyllie, 2006). 3. AMPA and Kainate Receptors AMPA and kainate receptors mediate the majority of fast excitatory synaptic currents in the nervous system. Although there is evidence for separated AMPA and kainate receptors, these receptors are activated by the same agonists with different affinities (Bettler and Muller, 1994).

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Subunit assembly of Nmethyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer. J Biol Chem, 280, 24923-30. 16 Patrizia Guida, Paola Gavazzo and Carla Marchetti Steinmetz, R. , Nicotera, P. & Steinhilber, D. (2002). A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods, 113, 99-110. , Wang, J. , Li, J. , Zhu, W. , Wang, Y. , Luo, J. , Wolfe, B. B. & Grayson, D. R. (1998). Functional and pharmacological differences between recombinant N-methyl- D-aspartate receptors.

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