By Michael R. Pinsky, Laurent Brochard, Jordi Mancebo, Göran Hedenstierna
In conception, therapy judgements and tests of reaction to treatment in severely ailing sufferers should still often be in line with measures of physiological functionality. however, the main applicable use of the knowledge embodied in such measures is usually uncertain, and infrequently supported through potential scientific trials. in truth, the bedside clinician is hence pressured to depend totally on physiological rules while selecting the simplest remedy. regrettably, even though, the mandatory wisdom base of the clinician is frequently under optimum for the aim, and behavior or past education should be extra influential than technology. in contrast heritage, this moment, revised version of utilized body structure in extensive Care drugs goals to assist conquer the basic unevenness in clinicians’ realizing of utilized body structure. it truly is divided into 3 sections. the 1st contains a chain of "physiological notes" that concisely and obviously trap the essence of the physiological views underpinning our knowing of disorder and reaction to treatment. the second one part comprises extra certain linked stories on size suggestions and physiological methods, whereas the 3rd presents a couple of seminal reviews on diversified themes in extensive care. This up to date compendium of useful bedside wisdom necessary to the potent supply of acute care medication has been written by way of essentially the most well known specialists within the box. it's going to serve the clinician as a useful reference resource on key matters usually faced in daily perform.
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Additional resources for Applied Physiology in Intensive Care Medicine (2nd Edition)
Feihl F (2003) Respiratory dead space and survival in the acute respiratory distress syndrome. In: Gullo A (ed) Anesthesia pain intensive care and emergency medicine, vol. 1. Springer, Berlin Heidelberg New York, pp 275– 287 9. Kline JA, Israel EG, Michelson EA, O’Neil BJ, Plewa MC, Portelli DC (2001) Diagnostic accuracy of a bedside D-dimer assay and alveolar dead space measurement for rapid exclusion of pulmonary embolism. JAMA 285:761– 768 10. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay A (2002) Pulmonary deadspace fraction as a risk factor for death in the acute respiratory distress syndrome.
Wagner PD (1982) Calculation of the distribution of ventilation/perfusion ratios from inert gas elimination data. Fed Proc 41:136–139 19. Hammond MD, Hempleman SC (1987) Oxygen diffusing capacity estimates derived from measured VA/Q distributions in man. Respir Physiol 69:129–147 20. West JB (1969) Ventilation/perfusion inequality and overall gas exchange in computer models of the lung. Respir Physiol 7:88–110 21. Young I, Mazzone RW, Wagner PD (1980) Identification of functional lung unit in the dog by graded vascular embolization.
Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay A (2002) Pulmonary deadspace fraction as a risk factor for death in the acute respiratory distress syndrome. N Eng J Med 346:1281–1286 Peter D. Wagner The multiple inert gas elimination technique (MIGET) Abstract This brief review centers on the multiple inert gas elimination technique (MIGET). This technique, developed in the 1970s, measures the pulmonary exchange of a set of six different inert gases dissolved together in saline (or dextrose) and infused intravenously.