Clinical Obesity by Peter G. Kopelman, Michael J. Stock

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By Peter G. Kopelman, Michael J. Stock

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After a period of time to allow the antigens present to bind to their cognate antibodies, bound antigen is detected using fluorescently tagged secondary antibodies. Alternatively lysates containing fluorescently tagged or radioactively labelled proteins can be added directly to the array to permit direct detection of the analyte. Currently, “cytokine-chemokine array” strategies appear to be more robust, since a number of well characterized reagents and commercial arrays are available and many disease syndromes display characteristic patterns of cytokine and chemokine expression.

4 Transcriptome and Transcriptomics Transcriptomics refers to the comprehensive scanning of the nearly fifty thousand currently known genes that are transcribed into RNA molecules from the three-billion-letter human genome. Each cell utilizes (expresses) different genes at different times in its development and under different physiological conditions. In general, tissues express similar sets of genes that can be used to identify those tissues in the absence of any other information. For example, the brain expresses about 30% of all of the known genes; those specific transcripts are different from the transcribed genome in the heart.

Over the past two decades, advances in genomic technology have allowed laboratories to generate vast amounts of biological data. These data include gene sequences, protein structures, information on gene expression and metabolic pathways. Automated instrumentation has enabled large volumes of data to be generated and automatically stored in computer databases, and this data has as many different formats as there are instruments. 4 Transcriptome and Transcriptomics 15 from genomic technologies, pharmaceutical and biotechnology companies have large amounts of “legacy data” – data inherited from their own and other sources on chemical structures and properties of compounds, and clinical, phenotypic and toxicological information.

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