Comparison of Type I and Type II Diabetes: Similarities and by Mladen Vranic

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By Mladen Vranic

Five years in the past, a brand new method of category of a number of the different types of diabetes was once proposed. This book presents an inte­ grated photo of the most recent info at the similarities and dissimilarites of 2 varieties of diabetes. It includes contributions from morphologists, physiologists, biochemists, immunologists, pathologists, geneticists, clinicians and epidemiologists. within the first part, the foundation for the current category and its barriers are mentioned. moreover, there's a dialogue of gestational diabetes and heterogeneity of a few sub-classes of diabetes. the subsequent part bargains with genetics and immunology. The 3rd part discusses abnormalities of insulin secretion and act ion on either the receptor and put up . . . receptor degrees. The function of gastrointestinal peptides in kind I and sort II diabetes is usually thought of. within the final part, either forms of diabetes are in comparison with admire to diabetic problems. The remaining sec­ tion summarizes the current prestige and provides a stimulating view of destiny improvement. we are hoping that this e-book could be an invaluable resource of data for either researchers and training clinicians. M. Vranic G. steiner C. H. Hollenberg v ACKNOWLEDGEMENTS The symposium from which this quantity arose (June 28-29, 1984) was once equipped through the Banting and top Diabetes Centre, collage of Toronto. we wish to precise our appreciation to the subsequent sponsors: Ames academic Institute, Ayerst Laboratories, Becton Dickinson Canada Inc. , Canadian gentle Drink organization, Connaught Laboratories constrained, Connaught Novo Ltd. , Eli Lilly Canada Inc.

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Extra resources for Comparison of Type I and Type II Diabetes: Similarities and Dissimilarities in Etiology, Pathogenesis, and Complications

Example text

What underlying mechanism(s) is (are) responsible? What are its pathogenic implications? Is the development of IGT a 'normal' phenomenon of ageing? Should it be 'treated' and if so, how? Is it an homogeneous entity or is it, to use a currently much overused term, heterogeneous? Follow-up studies S ,6,7,8,9 carried out in populations characterized initially by their glycaemic responses have contributed partial answers to some of these questions. Many individuals found on initial testing to show IGT revert, apparently spontaneouslY, to normal glucose tolerance, some of them no doubt illustrating the well-recognized statistical phenomenon of 'regression to the mean'.

In the already established diabetic patient, prophylaxis of diabetic retinopathy and nephropathy is likely also to be influenced by whether the condition has yet to make its first appearance (i. e. primary prevention of the complication), whether early changes are present but not yet affecting organ or tissue function, or whether organ failure or the high risk indicators for it, are demonstrable. This latter distinction is of importance for there appears to be a point of 'metabolic no return' in the evolution of the retinal and renal complications of DK beyond which correction of the diabetic state appears to have little influence on the abnormal tissue processes that it initiated.

They could be subclassified by mechanism (when known> . 6. g. 'Tropical or 'Nutritional' OM). 44 H. KEEN 7. A staging dimenston should be recognised in classifications of DK. 8. Future classifications will benefit from the incorporation of the presence or absence of susceptibility/resistance factors to diabetes itself or to its severe long term sequelae. 9. There remain uncertainties about the defini tions and clinical implications of gestational DK (and gestational IGT) not discussed above. 10.

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