Cytokines as Potential Therapeutic Targets for Inflammatory by R. Numerof, Charles A. Dinarello, Khusru Asadullah

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By R. Numerof, Charles A. Dinarello, Khusru Asadullah

Cytokines and cytokine receptors stay a space of significant curiosity for the improvement of distinctive remedies for cutaneous inflammatory ailments. Anti-TNF therapeutics have confirmed to be potent within the therapy of psoriasis, and medical investigations have now all started for different cytokine-directed cures, akin to these concentrating on IFN-g, IL-12p40, and IL-18. as well as therapeutics that concentrate on cytokines without delay, recommendations that concentrate on cytokine signaling pathways are in improvement. This ebook summarizes the findings of the 56th foreign Workshop of the Ernst Schering examine beginning that enthusiastic about "Cytokines as power healing pursuits for Inflammatory pores and skin Diseases".

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Extra resources for Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases (Ernst Schering Foundation Symposium Proceedings)

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Thereafter cytokines may be targeted in rodent models believed to reflect some component of human disease activity. Finally proof of concept trials may provide necessary data prior to continuing with appropriately powered placebo-controlled clinical trials. g. the relative disappointment of IL-1 blockade in humans relative to animal model studies. Nevertheless, this approach provides a useful basis upon which to discuss cytokine activities proposed as potential targets in chronic inflammatory diseases.

Curr Opin Neurol 16:359–365 Tang H, Mignon-Godefroy K, Meroni PL, Garotta G, Charreire J, Nicoletti F (1993) The effects of a monoclonal antibody to interferon-gamma on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells. Eur J Immunol 23:275–278 Tang L, Cao L, Bernardo O, Chen Y, Sundberg JP, Lui H, Chung S, Shapiro J (2003) Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes.

30 31 31 33 35 37 39 40 Abstract. Targeting TNFα provided proof of concept for the role of proinflammatory cytokines in promoting cutaneous inflammation, particularly psoriasis. Recent studies have elucidated the presence of numerous cytokine and chemokine activities in psoriatic skin and synovium. There is considerable interest in the potential of such activities as novel therapeutic targets.

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