Derm notes Dermatology Clinical Pocket Guide by Jim E. Riviere

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By Jim E. Riviere

Many experimental tools and mathematical modeling ways rooted in disciplines open air of toxicology may be successfully utilized to estimating dermal absorption. Dermal Absorption versions in Toxicology and Pharmacology explores present methods and strategies that may be used to quantify dermal absorption with endpoints precious in either toxicology and pharmacology. The e-book starts with a overview of simple rules and the in vitro and in vivo experimental techniques on hand for assessing dermal absorption of substances and chemical compounds. this can be by way of insurance of mathematical or in silico versions for quantitating percutaneous absorption and the purposes of those recommendations to the danger review technique. the rest of the booklet explores situations the place the original houses of the chemical compounds being studied or the matrix within which they're uncovered needs to be thought of after which wraps up with a comparative research of chemical permeability in human and animal dermis. the various books protecting this topic are only too finished and serve essentially as reference works. This ebook takes a distinct method. Jim Riviere's editorial information guarantees that the data is readable, obtainable, authoritative, and concise, making it the suitable source for familiarizing new researchers and scholars to the sector and updating proven scientists.

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50 Stratum corneum Epidermis Dermis Dermal vessels Subcutaneous fat KTP 532 nm PDL Ruby Alexandrite Diode Nd:YAG 585-600 694 755 800 1064 nm nm nm nm nm Depth of Penetration by Various Lasers Excimer Nd:YAG CO2 Argon 193 2940 10,600 488-514 nm nm nm nm TX Page 51 12:13 PM 3/28/06 03Barankin(F)-03 51 04Barankin(F)-04 3/28/06 12:13 PM Page 52 A-F Acanthosis Nigricans (AN) Etiology: May be due to: a. Heredity b. , diabetes mellitus), hyperandrogenic state, hypothyroidism c. Obesity d. , nicotinic acid, niacinamide, oral contraceptives, steroids e.

Lupus erythematosus Reprinted with permission from Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology, edition 5 by Wolff, Suurmond, and Johnson. McGraw-Hill Professional Publishing. , psoriasis, lichen simplex chronicus, chronic eczema) Cream ■ Emulsion of oil in water ■ Less moisturizing than ointments, but more cosmetically appealing ■ Useful in acute and subacute dermatoses Gel ■ ■ ■ ■ Usually alcohol-based, transparent and colorless Liquefies on contact with skin Nongreasy, non-occlusive, nonstaining Use in hair-bearing areas or when drying is desired Solution ■ A liquid vehicle: propylene glycol, water or alcohol ■ Useful under cosmetics, in hair-bearing regions, and when drying is desired Lotion ■ Suspension of a powder in water; leaves a film of uniform powder on skin ■ Less moisturizing than a cream ■ Good for hair-bearing areas Foams ■ Any area, but especially scalp ■ Easy application, with less grease/residue Powders ■ Promote drying ■ Used in intertriginous areas to reduce moisture, friction, maceration Paste ■ Mixture of powder and ointment ■ Ihle’s paste used for diaper and intertriginous dermatitis 32 03Barankin(F)-03 3/28/06 12:13 PM Page 33 33 Topical Steroids Memorize and become comfortable prescribing 1 to 2 topical steroids within each steroid potency group.

Management is difficult and mostly for cosmetic purposes. ■ Tx options: Topical tretinoin, ammonium lactate, laser therapy, dermabrasion. Acne Vulgaris Inflammatory disorder of pilosebaceous follicles with a 90% prevalence in adolescence and young adulthood. A-F 04Barankin(F)-04 3/28/06 12:13 PM Page 54 A-F Etiology: Abnormal follicular keratinization, increased sebum 2Њ to androgens, Propionibacterium acnes (bacteria), inflammation. Genetic factors; occlusive cosmetic agents; medications: steroids, ACTH, androgens, danazol, iodides, lithium, antiepileptics, oral contraceptives; diseases: congenital adrenal hyperplasia (CAH), polycystic ovarian syndrome (PCOS); worse with emotional stress.

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