Dermatopathology by Eva Brehmer-Andersson

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By Eva Brehmer-Andersson

This publication introduces the rules of microscopic pathology of received epidermis ailments in a concise, but accomplished demeanour. The underlying mechanisms of the various ailments are mentioned near to sleek wisdom approximately immunology, molecular biology, and inflammatory reaction to infections and damage. The booklet is amply illustrated and CD-ROM permits growth of the illustrations.

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The beta 2 integrins, also called the leukocyte integrins, are expressed only on cells of lymphoid and myeloid lineage, and those of interest here are leukocyte function antigen 1 (LFA-1) and macrophage activation antigen 1 (MAC-1). Immunoglobulin Gene Family The immunoglobulin gene family is a large group of molecules which structurally resemble immunoglobulins; only a few of them are CAMs. Those relevant here are intercellular adhesion molecule 1 (ICAM-1), intercellular adhesion molecule 2 (ICAM-2), common differentiation antigen 2 (CD2), leukocyte function antigen 3 (LFA-3) and vascular cell adhesion molecule 1 (VCAM-1).

5). 2 (by means of pseudopodia) into the surrounding tissue Foreign Body Granuloma and they then proliferate (by mitotic activity) towards Foreign body granulomas are caused by non-antigenic the angiogenic stimulus. Thus, in the perivascular tismaterial such as silica and suture material. They con- sue, at first a sprout and then a cord of endothelial cells sist mainly of macrophages and foreign body giant are formed. 5 Cell Division Fig. 7 Mitotic figures: a prophase; b metaphase; c anaphase; d anaphase; e telophase; f telophase, the cell to the left of the mitotic figure is in interphase; g atypical metaphase.

Interleukin is a general term for a group of multifunctional cytokines that are produced by a variety of lymphoid and non-lym- Fig. 2 Adhesion molecules. The cell membrane which is made up of two rows of lipid molecules contains two different transmembrane adhesion molecules. One is a protein, the other a glycoprotein (illustrator Edward Brehmer; reproduced from Brehmer-Andersson E (1988), with permission) phoid cells. ). Other important cytokines are IFN-α, IFN-β and IFN-γ, tumor necrosis factor (TNF) alpha and beta, transforming growth factor (TGF) beta, and lipopolysaccharide (LPS).

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