Dermatotoxicology by Klaus Peter Wilhelm, Hongbo Zhai, Howard I. Maibach

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By Klaus Peter Wilhelm, Hongbo Zhai, Howard I. Maibach

The foundational reference in dermal toxicology, this vintage textual content has been thoroughly revised to carry it modern within the new 8th version, with virtually a 3rd of its chapters being newly extra. The constitution of the textual content has additionally been reorganized to allow more uncomplicated situation of a subject matter of curiosity. With contributions from major foreign specialists, this keeps the culture of offering unsurpassed theoretical and useful suggestions for all these engaged on learn features, on functional medical matters, and at the regulatory features of publicity to poisonous substances.

This new version includes updates to every bankruptcy and contributions from major foreign specialists, offers an in-depth precis of analysis and regulatory purposes concerning dermal toxicology and pharmacology, provides many new chapters that describe the most recent advances in dermatotoxicology, and addresses numerous degrees of craftsmanship in regards to the improvement and use of dermal publicity facts. New chapters contain these on safety terminology, pharmacogenetics and dermatology, ethnic modifications in dermis houses, and the rules and perform of percutaneous absorption.

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Evidence-based medicine: a possible model for evidence-based toxicology? Hum Exp Toxicol 2009; 28: 105–7. 6. Scherer RW. 2 Evidence-based health care and the cochrane collaboration. Hum Exp Toxicol 2009; 28: 109–11. 7. Schneider K, Schwarz M, Burkholder I, et al. “ToxRTool,” a new tool to assess the reliability of toxicological data. Toxicol Lett 2009; 189: 138–44. 8. Bus JS, Becker RA. Toxicity testing in the 21st century: a view from the chemical industry. Toxicol Sci 2009; 112: 297–302. 9. Hartung T.

2 suggested that the presence of hormesis in cancer biology may be an important phenomenon not to be overlooked. Despite the extensive observation of hormetic dose–response relationships for numerous agents across the biological spectrum, most studies assessed cellular responses. Few studies followed up in animal and human models—normal or disease—assessed the simultaneous responses of different systems to the same agent. We believe in vivo studies are necessary to provide an integrative assessment of the whole animal/human responses to various agents, to document any discrepancies between the in vitro and in vivo responses, and to clarify the clinical implication of hormesis.

The work of Schneider et al. (7) places itself specifically in the frame of EBT. By means of two rating experiments assessing a range of toxicologic papers, appraisal tools were developed and improved for in vitro and in vivo methods. Although of potential use as a tool for the assessment of (eco-)toxicologic studies and publications, as for example required according to the new European Chemical Regulation REACH (Registration, Evaluation and Authorisation of Chemicals) when submitting data, it seems that it has not been used to any major extent.

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