Drug Therapy for Type 2 Diabetes by Andrew Krentz

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By Andrew Krentz

This Adis Pocket Reference provides an updated, succinct, and functional method of drug treatment for kind 2 diabetes.

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Drug Therapy for Type 2 Diabetes

This Adis Pocket Reference provides an updated, succinct, and sensible method of drug treatment for sort 2 diabetes.

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Nonetheless, in practice tolerability is frequently a major issue in UK practice. In contrast, acarbose is more widely used in some other countries; China for example. 5 Efficacy As monotherapy, these agents can reduce peak postprandial glucose concentrations by 1–4 mmol/l. The effects on fasting hyperglycaemia are less impressive, usually less than 1 mmol/l. 0%, if a relatively high dose is tolerated. The theoretical cardiovascular benefits of preferentially reducing postprandial hyperglycaemia found support in the STOP–NIDDM (Study to Prevent Non-Insulin-Dependent Diabetes Mellitus) trial; these observations await confirmation.

Although single tablets could reduce titration flexibility, most of the commonly used dosage combinations are available. Any combination therapy necessitates the same cautions and contraindications that apply to each active component. 8. Principles of insulin therapy in type 2 diabetes Clinical experience with insulin is unrivalled among glucose-lowering drug therapies. Clinical trials have demonstrated delayed onset and progression of vascular complications with reduced morbidity and mortality in patients with type 2 diabetes.

The PPARg-mediated transcriptional effects of thiazolidinediones on target genes improve whole-body insulin sensitivity. Troglitazone was the first thiazolidinedione to enter clinical use in 1997. However, the drug was associated with cases of fatal hepatotoxicity; it was withdrawn in 2000, having been available for only a few weeks in the UK. Two other thiazolidinediones, rosiglitazone and pioglitazone, which have not shown this hepatotoxicity, were introduced in the USA in 1999 and in Europe in 2000.

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