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Serotonin and Sleep: Molecular, practical, and scientific elements covers the total spectrum of the sector and explores the hyperlink among the newest simple molecular, useful, and scientific facets of serotonin and the perform of sleep medication. the quantity specializes in 24 diverse parts of analysis, with distinct emphasis concerning the country of simple and medical study to power functions: altering innovations in serotonin learn, topographic association and chemoarchitecture, receptor mechanisms its association and rules of behavioral states, electrophysiological mechanisms in vitro, in vivo, and behaving animals and different parts of molecular neurobiology. additionally highlighted are stories concerning the circadian keep an eye on of behavioral states, and mechanisms eager about the serotonergic inhibition of REM sleep. Such dialogue has profound implications for the fundamental biology of serotonin. This distinctive quantity not just explores the state-of-the-art study, and the connection of serotonin to laboratory animals in addition to human sleep; it additionally explores the relevance of serotonin to medical issues resembling melancholy, schizophrenia, and sleep apnea and brings those components jointly to proceed to advertise the fast growth of information within the quarter of serotonergic neurotransmission throughout behavioral states. Written via a global cadre of researchers, this well timed quantity offers an up to date precis of what could be the simply view on serotonin from the views of neurobiologists, neuroanatomists, mobilephone biologists, psychiatrists, neuropharmacologists, in addition to sleep researchers.
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Extra resources for Serotonin and sleep: molecular, functional and clinical aspects
Another area that has been implicated in the generation of REM sleep is an area adjacent to the locus coeruleus, peri-locus coeruleus alpha in the mediodorsal pontine tegmentum . This area is not suppressed by serotonin . The different areas implicated in REM sleep may be important for the different physiological aspects of this sleep stage (atonia, PGO activity, EEG desynchronization), and these areas may interact to generate REM sleep . There is a complex interaction of serotonin and other neurotransmitters and neuromodulators in the regulation of REM sleep.
Some populations of putative atypical serotonergic neurons appear to be topographically organized within the DR . The typical focus on the DR and MnR as the main serotonergic cell groups with ascending projections to forebrain structures may perpetuate a “fallacy of the excluded middle”. , the B9 (supralemniscal cell group)] appear to consist of an equal or greater number of serotonergic cells relative to the MnR, and different cell groups, and even subregions of these groups, appear to have unique chemoarchitectonic, hodological (connectivity), and functional properties.
J Physiol 126: 596–618 Brodie BB, Pletscher A, Shore PA (1955) Evidence that serotonin has a role in brain function. Science 122: 968 Brodie BB, Shore PA (1957) A concept for a role of serotonin and norepinephrine as chemical mediators in the brain. Ann N Y Acad Sci 66: 631–642 Aserinsky E, Kleitman N (1953) Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 118: 273–274 Dement W, Kleitman N (1957) Cyclic variations of EEG during sleep and their relation to eye movements, body motility, and dreaming.