Toxicology of Contact Hypersensitivity by Ian Kimber, Thomas Maurer

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By Ian Kimber, Thomas Maurer

An research of allergic touch dermatitis - a standard occupational illness affecting among 5-15% of the group. This booklet considers the situation from the viewpoint of the toxicologist instead of the dermatologist.

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Toxicology of Contact Hypersensitivity

An research of allergic touch dermatitis - a typical occupational illness affecting among 5-15% of the crew. This e-book considers the from the viewpoint of the toxicologist instead of the dermatologist.

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B) Proportion of subjects developing such reactions with different sensitizing doses. 5. It can be seen that as sensitizing dose increases so the challenge dose-response curve is shifted progressively to the left indicating greater reactivity. The fact that changing the strength of the sensitizing stimulus altered the position of the dose-response curve, but not its slope, is informative. The slope of the curve seems likely to be determined by the local inflammatory response, the increments of change being proportional to the log of the eliciting stimulus.

What contributes to the generation of the inflammatory response in the efferent stage? It is variability in these steps that probably accounts for the heterogeneity of immune responsiveness seen in human beings. However, despite the many steps that are involved in the generation of an immune response, the human immune system, like other physiological systems, exhibits tidy and generally predictable dose-response relationships. Using experimental sensitization with DNCB, analysis of these dose-response relationships has given a physiological perspective to many of the static and qualitative phenomena observed experimentally.

Points are numbers of vessels per 40× high power field. , 1993, with permission) 52 Clinical Aspects of Allergic Contact Dermatitis also show these qualitative differences in response to exposure to different types of provoking chemical. Conclusions In conclusion, studies of the clinical response of allergic contact dermatitis have led to a greatly increased understanding of the behaviour of the immune system, the recognition that independent of the immune status of the host, the skin can “sense” physical or chemical perturbation.

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